862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth
نویسندگان
چکیده
منابع مشابه
Macrophages and the tumor microenvironment
Macrophages and the tumor microenvironment Tumor tissue comprises a highly complex network of diverse cell types. In a simplified view, the tumor microenvironment can be subdivided into the cancer cell and the stromal cell compartments, the latter of which harbors many different cell types. A considerable number of innate immune cells reside within the tumor microenvironment, including macropha...
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When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates "metabolic checkpoints" ...
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In recent years, there is an increasing attention on the impact of the tumor microenvironment (TME) on tumor initiation, progression, and metastasis (1). Malignant tumor cells and non-malignant stromal cells actively interact with each other and thereby create a tumor-supportive microenviron-ment (2). TME is composed of extracellular matrix and several cell types, such as cancer-associated fibr...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2020
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-sitc2020.0862